When topical treatments for acne fail, such as benzoyl peroxide and salicylic acid, an oral treatment such as the drug Accutane (isotretinoin active ingredient) is often prescribed. This treatment is very effective because it decreases the production of oils (in the form of sebum) from the sebaceous glands present on the skin, as well as the size of these glands. Although incredibly effective, Accutane acne treatment carries some risks that will be discussed later.
Accutane acne treatment and, more specifically, the active ingredient (isotretinoin), is derived from the fat-soluble common vitamin, vitamin A. The specific compound used in the treatment of l? Acne Accutane is derived from the acidified form of this vitamin, giving Accutane the anti-acne properties of Vitamin A without many of the side effects.
Although it is not known exactly how Accutane acne treatment system does, it alters the process, by which the DNA is copied, and results in a smaller sebaceous gland (pore ) and, consequently, a lower production of sebum, the oil that accumulates on the skin. With smaller pores and less oil production, dead skin cells are much less likely to stick to the inside of a pore and clog it, forming a black spot. By reducing pore size and decreasing the amount of oil produced by them, Accutane acne treatment is able to significantly reduce the appearance of clogged pores, or acne. .
The dosage for the treatment of Accutane acne is very important. It is usually prescribed based on weight (between 0.5 and 2 mg of Accutane per kilogram of body weight per day). Normal treatment lasts between 4 and 6 months, but in extreme cases, there is a strong acne after the treatment is completed, Accutane can be prescribed again 2 months after the end of the initial prescription. Due to the highly non-polar nature of the compound used in Accutane, it is very soluble in fats. This means that it is better absorbed into the bloodstream after a high-fat meal because the fat molecules will provide a way for the dissolved isotretinoin to be absorbed into the bloodstream. The dosage and timing of Accutane acne treatment can greatly affect the overall effectiveness of the product.
Like many drugs, Accutane acne treatment presents some potential risks. The most common side effects of Accutane are directly related to the decreased production of sebum in the skin. These side effects are dryness of the skin and lips, itching, rashes, peeling and fragile skin. There are also some side effects related to decreased sebum production in the eyes, such as conjunctivitis, dry eye, and reduced tolerance to contact lenses. In addition, because fats and albumin are used to transport the isotretinoin molecule found in Accutane, these levels may be slightly increased. Less common side effects may include severe acne breakouts, mood swings or fatigue. Although only exposed in a very small portion of Accutane users, there was an increased rate of depression and suicide. Finally, the active drug used in the treatment of Accutane acne is classified as an "FDA pregnancy category X", and its use during pregnancy usually results in miscarriage. Notable drug interactions include vitamin A supplements, as well as a certain drug used in the fight against cancer and autoimmune diseases, known as methotrexate.